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The transient or permanent middle cerebral artery occlusion (MCAo) model is one of the models that most closely simulate human ischemic stroke. Furthermore, this model is characterized by reliable and well-reproducible infarcts.What is the normal score for MCAO in rats?
Total neurological score at various times after 60 minutes (A) and 2 hours (B) of MCAo in rats with uncoated sutures (n=8 and 6, respectively) and poly- l -lysine−coated sutures (n=7 and 4, respectively). Normal score, 0; maximal score, 12. Data are presented as mean±SEM.What are the advantages of the MCAO model?
The MCAo model has several advantages: First, this model mimics human ischemic stroke, which often originates from an MCAo, and exhibits a penumbra that is similar to that of human stroke. Furthermore, the MCAo model is characterized by large infarct volumes and high reproducibility.What does MCAO stand for?
The intraluminal suture method of middle cerebral artery occlusion (MCAO) in the rat (the suture model) is a model of stroke which readily lends itself to studying the pathophysiology of post-ischaemic reperfusion.