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What is periventricular leuko-ventricular (PVL) disease?

The condition involves the death of small areas of brain tissue around fluid-filled areas called ventricles. The damage creates "holes" in the brain. "Leuko" refers to the brain's white matter. "Periventricular" refers to the area around the ventricles. PVL is much more common in premature infants than in full-term infants.

What is the pathophysiology of PVL?

PVL is much more common in premature infants than in full-term infants. A major cause is thought to be changes in blood flow to the area around the ventricles of the brain. This area is fragile and prone to injury, especially before 32 weeks of gestation. Infection around the time of delivery may also play a role in causing PVL.

What does PVL stand for?

DCCA Home Professional and Vocational Licensing (PVL) The Department of Commerce and Consumer Affairs resumed most walk-in services during normal business hours between 7:45 a.m. to 4:30 p.m., Monday through Friday, excluding state holidays. Please observe proper safety protocols (e.g., face covering and physical distancing) when visiting.

What is the prognosis of PVL?

There is no treatment for PVL and the prognosis varies depending on the severity of the damage to the brain. Clinicians in Boston Children’s Fetal Neonatal Neurology Program provide early and accurate diagnosis of PVL and other brain injuries acquired by newborns and young infants.


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