Keyword Analysis & Research: mcao model of stroke


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Frequently Asked Questions

Is the MCAO model a valid model for stroke research?

While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model. Various factors exert important effects on the outcome in this stroke model, including the age and sex of the animal examined.

Is the middle cerebral artery occlusion model appropriate for stroke research?

The middle cerebral artery occlusion (MCAO) model has been utilized extensively, especially in rodents. While the MCAO model provides stroke researchers with an excellent platform to investigate the disease, controversial or even paradoxical results are occasionally seen in the literature utilizing this model.

What does MCAO stand for?

Middle cerebral artery occlusion (MCAO) is a commonly used stroke model in mice and rats. A filament is inserted to the artery to occlude blood flow for a fixed period of time (usually 30-120 mins) before removal for reperfusion resulting in ischemic stroke. (2), (3), (4), (5), (6), (7), (8), (9), (10).

Is there an animal model of stroke?

Since most ischemic strokes (~80%) occur in the territory of middle cerebral artery (MCA), many animal stroke models that have been developed have focused on this artery.


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