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Wounded Knee held a special significance for American Indians. It was the site of the 1890 Wounded Knee massacre of 200 to 300 Sioux Indians by federal forces, considered to be the last major conflict of the Indian Wars.Who was involved in the Wounded Knee Massacre?
Wounded Knee. It involved the 7th US Cavalry under Colonel James W. Forsyth who clashed with the Lakota Sioux. The Lakota Sioux were led by Spotted Elk, also known as Big Foot. The conflict resulted in the massacre of nearly 400 Lakota Sioux the majority of which were women and children.