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HGBV-C RNA was identified in serum by a reverse-transcription–polymerase-chain-reaction assay with nested primers deduced from a nonstructural region. A nucleotide sequence of 100 bp in the nonstructural region was determined on HGBV-C clones.What is hepatitis GB virus a and B?
A GB hepatitis agent isolated in 1967 from a surgeon (whose initials were G.B.) with acute hepatitis has been propagated in tamarins. It has turned out to be two novel RNA viruses of the Flaviviridae family, which are known as hepatitis GB virus A (HGBV-A) and hepatitis GB virus B (HGBV-B).What is the prevalence of hepatocellular carcinoma (hgbv-C) in Japan?
HGBV-C RNA was detected in 4 of 448 apparently healthy blood donors (0.9 percent) in Japan who were older than 30 years (303 men and 145 women; mean [±SD] age, 43±9 years). The frequency of HGBV-C was significantly lower in control subjects than in the patients on maintenance hemodialysis (0.9 percent vs. 3.1 percent, P<0.03).